Petr Vrba joined the scene of improvised music in 2005 with his collaboration with the Slovakian band Eduardo Borsuci In Optima Forma (later Sound brigade). Since then his unrelenting explorations of non-idiomatic improvisation using trumpets, clarinet, vibrating speakers, egg cutters etc., made him one of the most active experimental musicians in Prague.
In 2010 he became one of the founding members of improvisational ensemble IQ+1 which released a highly acclaimed CD Tváří v tvář in 2011. In the same year, he constituted Yanagi duo with experimenter Ryu Hankil (alarm clock, typewriters). With American musician/composer George Cremaschi (doublebass, electronic) they have regular duo and play also with invited musician as a trio like with Chris Heenan (contrabass clarinet, alt sax) or Susanna Gartmayer (bass clarinet). Since 2012 Vrba also regularly collaborates with sax player/composer from Slovakia Miro Tóth, and explores the possibilities of audiovisual improvisation with SeEun Lee and Ken Ganfield in project Total Verquert. In 2012 with George Cremaschi they founded Prague Improvisation Orchestra. Recently he started to collaborate with Maja Osojnik and Matija Schellander under so called doppeltrio in which every player uses an acoustic, as well as an electronic instrument. Osojnik is playing on a sub-bass flute and on the different electronic devices, Schellander on doublebass and on modular synthesizer and Vrba, beside trumpet, uses his bizarre vibrating speakers. For other projects, including dance collaboration, releases etc see his webpage. Since 2010 he curates the musical programme of Communication Space Školská 28 which is a multifunctional space for various nonprofit cultural and artistic activities.
Since 1994 he plays as a DJ at Radio 1 in Prague, and was also a temporary student of gamelan music at Institute of Art of Indonesia in Yogyakarta (1997–1998).